Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs)
in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists …

CD4 + T cells are critical regulators of immune responses, but their functional role in human
breast cancer is relatively unknown. The goal of this study was to produce an image of CD4 …

Assessment of the immune response to tumors is growing in importance as the prognostic
implications of this response are increasingly recognized, and as immunotherapies are …

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide
important prognostic information in diverse solid tumor types, and may also be of value in …

T follicular helper cells (T FH cells) are important regulators of antigen-specific B cell responses.
The B cell chemoattractant CXCL13 has recently been linked with T FH cell infiltration …

Early detection and treatment are critical for improving the outcome of patients with cancer 1
. Understanding the largely uncharted biology of carcinogenesis requires deciphering …

Multiple independent studies have shown that tumor-infiltrating lymphocytes (TIL) are prognostic
in breast cancer with potential relevance for response to immune-checkpoint inhibitor …

We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13-…

Tumor-infiltrating B cells (TIL-B) in breast cancer (BC) have previously been associated with
improved clinical outcomes; however, their roles in tumor immunity are not currently well …

The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly
improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has …