… DNA was extracted by proteinase K digestion followed by ethanol precipitation. PCR reaction
were conducted using primers in Supplementary Table 6 and LongAMP polymerase (NEB) …

Hypertension is a complex disease that affects a large proportion of adult population. Although
approximately half of the inter-individual variance in blood pressure (BP) level is heritable…

Repair of Cas9-induced double-stranded breaks results primarily in formation of small
insertions and deletions (indels), but can also cause potentially harmful large deletions. While …

INTRODUCTION: Recurrent miscarriage (RM; ≥3 consecutive pregnancy losses) occurs in
1–3% of fertile couples. No biomarkers with high predictive value of threatening miscarriage …

Nat. Biotechnol. 10.1038/nbt. 4192; corrected online 31 July 2018 In the version of this article
initially published online, four figure citations were incorrect on p. 2: left-hand column, after" …

We have combined random 6 amino acid substrate phage display with high throughput
sequencing to comprehensively define the active site specificity of the serine protease thrombin …

… of aggregate mutations in VWF73 on k cat /K M with the per site rate of evolution in vertebrate
orthologous sequences (41, 42). Sites with a greater effect on k cat /K M tended to evolve …

In humans, loss of function mutations in SEC23B result in Congenital Dyserythropoietic
Anemia type II (CDAII), a disease limited to defective erythroid development. Patients with two …

The COPII component SEC24 mediates the recruitment of transmembrane cargos or cargo
adaptors into newly forming COPII vesicles on the ER membrane. Mammalian genomes …

… Vendt N, Kool P, Tomberg K, Grünberg H. Rauapuuduse ja rauapuudusaneemia levimus
ning põhjused Tartu 9–12 elukuu vanustel imikutel. (Iron deficiency anaemia – prevalence and …