Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

The nuclear receptors liver X receptor (LXR)α and LXRβ are sensors of cholesterol metabolism
and lipid biosynthesis. They have recently been found to be regulators of inflammatory …

Objectives This study aimed to provide timely and effective guidance for pregnant women
and health care providers to optimize maternal treatment and fetal protection and to promote …

Background Data are limited regarding the use of poly(adenosine diphosphate [ADP]–ribose)
polymerase inhibitors, such as veliparib, in combination with chemotherapy followed by …

A major burden in the treatment of ovarian cancer is the high percentage of recurrence and
chemoresistance. Cancer stem cells (CSCs) provide a reservoir of cells that can self-renew, …

The Greenland shark (Somniosus microcephalus), an iconic species of the Arctic Seas,
grows slowly and reaches >500 centimeters (cm) in total length, suggesting a life span well …

Sterol metabolism has recently been linked to innate and adaptive immune responses
through liver X receptor (LXR) signaling. Whether products of sterol metabolism interfere with …

Background Awareness is growing that cancer can be treated during pregnancy, but the effect
of this change on maternal and neonatal outcomes is unknown. The International Network …

Liver X receptors (LXRs) are nuclear hormone receptors that regulate cholesterol and fatty
acid metabolism in liver tissue and in macrophages. Although LXR activation enhances …

Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore,
it would not be surprising that factors that function in the tissue repair process, such as …