Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated
with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health.
To date, most genetic studies of glycemic traits have focused on individuals of European …

C-reactive protein (CRP) is a sensitive biomarker of chronic low-grade inflammation and is
associated with multiple complex diseases. The genetic determinants of chronic inflammation …

Bone mineral density (BMD) assessed by DXA is used to evaluate bone health. In children,
total body (TB) measurements are commonly used; in older individuals, BMD at the lumbar …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we …

Lifespan is a trait of enormous personal interest. Research into the biological basis of
human lifespan, however, is hampered by the long time to death. Using a novel approach of …