Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying development,
disease, and regeneration. As organoid research expands, the need for clear definitions …

The long-lasting success of forward genetic screens relies on the simple molecular basis of
the characterized phenotypes, which are typically caused by mutations in single genes. …

New sequencing technologies are dramatically accelerating progress in forward genetics,
and the use of such methods for the rapid identification of mutant alleles will be soon routine …

… To estimate the most likely value of k, we averaged the clusteredness statistic 60 over all
repeats per k. We merged the different Q matrices with CLUMPP 61 and plotted population …

To take complete advantage of information on within-species polymorphism and divergence
from close relatives, one needs to know the rate and the molecular spectrum of …

We report the 207-Mb genome sequence of the North American Arabidopsis lyrata strain MN47
based on 8.3× dideoxy sequence coverage. We predict 32,670 genes in this outcrossing …

To the Editor: Traditional strategies for identification of causal mutations involve two discrete
steps: recombinant genotyping and candidate gene sequencing. To dramatically speed up …

Objectives. —To improve end-of-life decision making and reduce the frequency of a mechanically
supported, painful, and prolonged process of dying. Design. —A 2-year prospective …

INTRODUCTION The centromeres of eukaryotic chromosomes assemble the multiprotein
kinetochore complex and thereby position attachment to the spindle microtubules, allowing …

Whole-genome hybridization studies have suggested that the nuclear genomes of accessions
(natural strains) of Arabidopsis thaliana can differ by several percent of their sequence. To …