Synthetic lethal metabolic targeting of cellular senescence in cancer therapy

…, J Lisec, D Lenze, A Gerhardt, K Schleicher… - Nature, 2013 - nature.com
Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …

A new high pressure equation of state for seawater

…, CT Chen, A Bradshaw, K Schleicher - Deep Sea Research Part A …, 1980 - Elsevier
… in v - v P yields an error of + 4.07 in K while a + 5 ppm error in v yields an error of +0.15 in
K. … from the measurements by BRADSHAW and SCHLEICHER (unpublished results). The …

Structurally diverse dendritic libraries: A highly efficient functionalization approach using click chemistry

M Malkoch, K Schleicher, E Drockenmuller… - …, 2005 - ACS Publications
The high fidelity and efficiency of Click chemistry are exploited in the synthesis of a library of
chain end functionalized dendritic macromolecules. In this example, the selectivity of the Cu-…

Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling

…, K Schleicher, A Malik, R Quevedo, E Langille, K Teng… - Science, 2020 - science.org
In most human cancers, only a few genes are mutated at high frequencies; most are mutated
at low frequencies. The functional consequences of these recurrent but infrequent “long tail” …

[PDF][PDF] Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins

LE Kapinos, RL Schoch, RS Wagner, KD Schleicher… - Biophysical journal, 2014 - cell.com
Intrinsically disordered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes
exert multivalent interactions with transport receptors (Karyopherins (Kaps)) that orchestrate …

[HTML][HTML] Using cAMP sensors to study cardiac nanodomains

K Schleicher, M Zaccolo - Journal of cardiovascular development and …, 2018 - mdpi.com
3′,5′-cyclic adenosine monophosphate (cAMP) signalling plays a major role in the
cardiac myocyte response to extracellular stimulation by hormones and neurotransmitters. In …

Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy

G Subramaniam, K Schleicher, D Kovanich… - Circulation …, 2023 - Am Heart Assoc
Background: Signaling by cAMP is organized in multiple distinct subcellular nanodomains
regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling …

AJUBA: A regulator of epidermal homeostasis and cancer

K Schleicher, D Schramek - Experimental dermatology, 2021 - Wiley Online Library
The epidermis, outermost layer of the skin, is constantly renewing itself through proliferative
and differentiation processes. These processes are vital to maintain proper epidermal …

[HTML][HTML] Bod1 regulates protein phosphatase 2A at mitotic kinetochores

IM Porter, K Schleicher, M Porter… - Nature communications, 2013 - nature.com
Mitotic entry and progression require the activation of several mitotic kinases and the proper
regulation and localization of several phosphatases. The activity and localization of each of …

Direct measurement of thermal expansion of sea water under pressure

A Bradshaw, KE Schleicher - Deep Sea Research and Oceanographic …, 1970 - Elsevier
… (1) A run at 8 bars and 15C to determine the average area factor, A'15,8 + K. … K, in the area
factor, corrects for the dilation of the dilatometer flask with changing head of mercury. Since K