Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
…, J Lisec, D Lenze, A Gerhardt, K Schleicher… - Nature, 2013 - nature.com
Activated oncogenes and anticancer chemotherapy induce cellular senescence, a terminal
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …
growth arrest of viable cells characterized by S-phase entry-blocking histone 3 lysine 9 …
A new high pressure equation of state for seawater
…, CT Chen, A Bradshaw, K Schleicher - Deep Sea Research Part A …, 1980 - Elsevier
… in v - v P yields an error of + 4.07 in K while a + 5 ppm error in v yields an error of +0.15 in
K. … from the measurements by BRADSHAW and SCHLEICHER (unpublished results). The …
K. … from the measurements by BRADSHAW and SCHLEICHER (unpublished results). The …
Structurally diverse dendritic libraries: A highly efficient functionalization approach using click chemistry
M Malkoch, K Schleicher, E Drockenmuller… - …, 2005 - ACS Publications
The high fidelity and efficiency of Click chemistry are exploited in the synthesis of a library of
chain end functionalized dendritic macromolecules. In this example, the selectivity of the Cu-…
chain end functionalized dendritic macromolecules. In this example, the selectivity of the Cu-…
Rare driver mutations in head and neck squamous cell carcinomas converge on NOTCH signaling
In most human cancers, only a few genes are mutated at high frequencies; most are mutated
at low frequencies. The functional consequences of these recurrent but infrequent “long tail” …
at low frequencies. The functional consequences of these recurrent but infrequent “long tail” …
[PDF][PDF] Karyopherin-centric control of nuclear pores based on molecular occupancy and kinetic analysis of multivalent binding with FG nucleoporins
LE Kapinos, RL Schoch, RS Wagner, KD Schleicher… - Biophysical journal, 2014 - cell.com
Intrinsically disordered Phe-Gly nucleoporins (FG Nups) within nuclear pore complexes
exert multivalent interactions with transport receptors (Karyopherins (Kaps)) that orchestrate …
exert multivalent interactions with transport receptors (Karyopherins (Kaps)) that orchestrate …
[HTML][HTML] Using cAMP sensors to study cardiac nanodomains
K Schleicher, M Zaccolo - Journal of cardiovascular development and …, 2018 - mdpi.com
3′,5′-cyclic adenosine monophosphate (cAMP) signalling plays a major role in the
cardiac myocyte response to extracellular stimulation by hormones and neurotransmitters. In …
cardiac myocyte response to extracellular stimulation by hormones and neurotransmitters. In …
Integrated proteomics unveils nuclear PDE3A2 as a regulator of cardiac myocyte hypertrophy
G Subramaniam, K Schleicher, D Kovanich… - Circulation …, 2023 - Am Heart Assoc
Background: Signaling by cAMP is organized in multiple distinct subcellular nanodomains
regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling …
regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic signaling …
AJUBA: A regulator of epidermal homeostasis and cancer
K Schleicher, D Schramek - Experimental dermatology, 2021 - Wiley Online Library
The epidermis, outermost layer of the skin, is constantly renewing itself through proliferative
and differentiation processes. These processes are vital to maintain proper epidermal …
and differentiation processes. These processes are vital to maintain proper epidermal …
[HTML][HTML] Bod1 regulates protein phosphatase 2A at mitotic kinetochores
Mitotic entry and progression require the activation of several mitotic kinases and the proper
regulation and localization of several phosphatases. The activity and localization of each of …
regulation and localization of several phosphatases. The activity and localization of each of …
Direct measurement of thermal expansion of sea water under pressure
A Bradshaw, KE Schleicher - Deep Sea Research and Oceanographic …, 1970 - Elsevier
… (1) A run at 8 bars and 15C to determine the average area factor, A'15,8 + K. … K, in the area
factor, corrects for the dilation of the dilatometer flask with changing head of mercury. Since K …
factor, corrects for the dilation of the dilatometer flask with changing head of mercury. Since K …