Highlights • Conceptual foundations of the drug repurposing paradigm are reviewed. •
Description of the technological trends behind the raise of in silico repurposing. • The different …

… end points available for comparison F, J, K). The highest increase in performance was
achieved on neuroblastoma event free survival (end point K) (0.894 against 0.575 for the best …

The field of biogerontology and regenerative medicine is rapidly evolving with many new
advances in aging research promising to transform healthcare and extend healthy productive …

High throughput technologies opened a new era in biomedicine by enabling massive
analysis of gene expression at both RNA and protein levels. Unfortunately, expression data …

A new generation of anticancer therapeutics called target drugs has quickly developed in
the 21 st century. These drugs are tailored to inhibit cancer cell growth, proliferation, and …

Reassortments and point mutations are two major contributors to diversity of Influenza A
virus; however, the link between these two processes is unclear. It has been suggested that …

We recently proposed a new bioinformatic algorithm called OncoFinder for quantifying the
activation of intracellular signaling pathways. It was proved advantageous for minimizing …

A subset of patients with oral squamous cell carcinoma (OSCC), the most common subtype
of head and neck squamous cell carcinoma (HNSCC), harbor dysplastic lesions (often …

… Wolterbeek performed statistical analyses for fiber size distribution; KV Lezhnina performed
pathway analyses using the OncoFinder method; IV Ozerov and AM Aliper developed the …

The COVID-19 pandemic and geopolitical crises have had a significant impact on the
international financial system in both the short and long term. Governments and central banks …