The Rosetta software for macromolecular modeling, docking and design is extensively used
in laboratories worldwide. During two decades of development by a community of …

Sustainable agriculture in response to increasing demands for food depends on development
of high-yielding crops with high nutritional value that require minimal intervention during …

Organic farming is based on the concept of working ‘with nature' instead of against it; however,
compared with conventional farming, organic farming reportedly has lower productivity. …

… Thus, for each water site k with coordinates v i,k , we compute an occlusion measure d k 2 to
… )Next, we find the soft minimum of d k 2 over all water sites in by computing the logarithmic …

The discovery and design of biologically important RNA molecules is outpacing three-dimensional
structural characterization. Here, we demonstrate that cryo-electron microscopy can …

Background International fish trade reached an import value of 62.8 billion Euro in 2006, of
which 44.6% are covered by the European Union. Species identification is a key problem …

RNA-Puzzles is a collective experiment in blind 3D RNA structure prediction. We report
here a third round of RNA-Puzzles. Five puzzles, 4, 8, 12, 13, 14, all structures of riboswitch …

Single-particle cryogenic electron microscopy (cryo-EM) has become a standard technique
for determining protein structures at atomic resolution 1 , 2 – 3 . However, cryo-EM studies of …

The molecular mechanisms of exon definition and back-splicing are fundamental unanswered
questions in pre-mRNA splicing. Here we report cryo-electron microscopy structures of …

The domestication of new crops would promote agricultural diversity and could provide a
solution to many of the problems associated with intensive agriculture. We suggest here that …