… PLD treatment of intact cells usually results in the formation of PA as well as LPA (K.
Jalink, unpublished observations). It remains to be seen whether the ability of LPA to …

Lysophosphatidate (LPA), the simplest natural phospholipid, is highly mitogenic for quiescent
fibroblasts. LPA-induced cell proliferation is not dependent on other mltogens and is …

Lysophosphatidic acid (LPA) is a water-soluble phospholipid with hormone-like and growth-factor-like
activities. LPA activates a putative G-protein-coupled receptor in responsive cells, …

… We previously suggested that LPA- and thrombin-induced cell rounding and neurite
retraction is secondary to contraction of the cortical actin.cytoskeleton (Jalink and Moolenaar, …

Error-free repair of DNA double-strand breaks (DSBs) is achieved by homologous recombination
(HR), and BRCA1 is an important factor for this repair pathway 1 . In the absence of …

Transient receptor potential (TRP) cation channels represent a large and diverse family of
ion channels that act as important transducers of sensory information. The Melastatin …

Epac1 is a guanine nucleotide exchange factor for Rap1 that is activated by direct binding
of cAMP. In vitro studies suggest that cAMP relieves the interaction between the regulatory …

Actomyosin contractility regulates various cell biological processes including cytokinesis,
adhesion and migration. While in lower eukaryotes, α‐kinases control actomyosin relaxation, a …

Drosophila phototransduction is a G protein–coupled, calcium-regulated signaling cascade
that serves as a model system for the dissection of phospholipase C (PLC) signaling in vivo. …

Mammalian interphase chromosomes interact with the nuclear lamina (NL) through hundreds
of large lamina-associated domains (LADs). We report a method to map NL contacts …