[HTML][HTML] The impact of malaria parasitism: from corpuscles to communities
TE Wellems, K Hayton… - The Journal of clinical …, 2009 - Am Soc Clin Investig
Malaria continues to exert a tremendous health burden on human populations, reflecting
astonishingly successful adaptations of the causative Plasmodium parasites. We discuss here …
astonishingly successful adaptations of the causative Plasmodium parasites. We discuss here …
Genetic linkage and association analyses for trait mapping in Plasmodium falciparum
X Su, K Hayton, TE Wellems - Nature Reviews Genetics, 2007 - nature.com
Genetic studies of Plasmodium falciparum laboratory crosses and field isolates have
produced valuable insights into determinants of drug responses, antigenic variation, disease …
produced valuable insights into determinants of drug responses, antigenic variation, disease …
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
Chloroquine (CQ) resistance (CQR) in Plasmodium falciparum originated from at least six
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …
foci in South America, Asia, and Oceania. Malaria parasites from these locations exhibit …
[PDF][PDF] Erythrocyte binding protein PfRH5 polymorphisms determine species-specific pathways of Plasmodium falciparum invasion
K Hayton, D Gaur, A Liu, J Takahashi, B Henschen… - Cell host & …, 2008 - cell.com
… role for the position 204 I / K substitution in A. nancymaae receptor binding and invasion. …
nancymaae erythrocytes correlated completely with binding of a PfRH5 Mr 28 K fragment …
nancymaae erythrocytes correlated completely with binding of a PfRH5 Mr 28 K fragment …
[HTML][HTML] Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria
…, GR Ostera, JS Wallach, HL Hoang, K Hayton… - Nature, 2005 - nature.com
Haemoglobin C, which carries a glutamate-to-lysine mutation in the β-globin chain, protects
West African children against Plasmodium falciparum malaria 1 , 2 . Mechanisms of …
West African children against Plasmodium falciparum malaria 1 , 2 . Mechanisms of …
Indels, structural variation, and recombination drive genomic diversity in Plasmodium falciparum
…, L Ranford-Cartwright, M Ferdig, K Hayton… - Genome …, 2016 - genome.cshlp.org
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation
to evade host immunity and develop drug resistance. Current understanding of parasite …
to evade host immunity and develop drug resistance. Current understanding of parasite …
Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum
P Rohrbach, CP Sanchez, K Hayton, O Friedrich… - The EMBO …, 2006 - embopress.org
The P‐glycoprotein homolog of the human malaria parasite Plasmodium falciparum (Pgh‐1)
has been implicated in decreased susceptibility to several antimalarial drugs, including …
has been implicated in decreased susceptibility to several antimalarial drugs, including …
Of mice and malaria mutants: unravelling the genetics of drug resistance using rodent malaria models
JMR Carlton, K Hayton, PVL Cravo, D Walliker - Trends in parasitology, 2001 - cell.com
It is well recognized that drug resistance is the most significant obstacle to gaining effective
malaria control. Despite the enormous advances in the knowledge of the biochemistry and …
malaria control. Despite the enormous advances in the knowledge of the biochemistry and …
A Multidomain Adhesion Protein Family Expressed in Plasmodium falciparum Is Essential for Transmission to the Mosquito
The recent sequencing of several apicomplexan genomes has provided the opportunity to
characterize novel antigens essential for the parasite life cycle that might lead to the …
characterize novel antigens essential for the parasite life cycle that might lead to the …
[HTML][HTML] High recombination rates and hotspots in a Plasmodium falciparum genetic cross
… where x i is the number of recombinants with regard to marker interval i and n is the total
number of progeny; k is the total number of marker intervals; and r i is the recombination fraction …
number of progeny; k is the total number of marker intervals; and r i is the recombination fraction …