DNA double-strand breaks: signaling, repair and the cancer connection
KK Khanna, SP Jackson - Nature genetics, 2001 - nature.com
To ensure the high-fidelity transmission of genetic information, cells have evolved mechanisms
to monitor genome integrity. Cells respond to DNA damage by activating a complex DNA-…
to monitor genome integrity. Cells respond to DNA damage by activating a complex DNA-…
Responsible research: A systems approach to protecting research participants
LL Rodriguez, KE Hanna, DD Federman - 2003 - books.google.com
When 18-year-old Jesse Gelsinger died in a gene transfer study at the University of Pennsylvania,
the national spotlight focused on the procedures used to ensure research participants' …
the national spotlight focused on the procedures used to ensure research participants' …
From selenium to selenoproteins: synthesis, identity, and their role in human health
The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …
has been known for several decades. This is attributed to low molecular weight selenium …
Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses
…, D Tung, M Miller, J Roix, KV Khanna… - Science translational …, 2014 - science.org
Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in
hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) …
hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) …
Hierarchical model-based motion estimation
This paper describes a hierarchical estimation framework for the computation of diverse
representations of motion information. The key features of the resulting framework (or family of …
representations of motion information. The key features of the resulting framework (or family of …
Wound healing after excimer laser keratomileusis (photorefractive keratectomy) in monkeys
FE Fantes, KD Hanna, GO Waring… - Archives of …, 1990 - jamanetwork.com
… Dr Hanna has a proprietary interest in the laser delivery system used in this study. None
of the other authors has a proprietary in¬ terest in the companies or materials involved in the …
of the other authors has a proprietary in¬ terest in the companies or materials involved in the …
Whole-genome landscape of pancreatic neuroendocrine tumours
…, KK Khanna… - Nature, 2017 - nature.com
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …
more sensitive detection methods, and this increase is creating challenges for clinical …
[HTML][HTML] Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4
Intestinal microbial metabolites are conjectured to affect mucosal integrity through an
incompletely characterized mechanism. Here we showed that microbial-specific indoles regulated …
incompletely characterized mechanism. Here we showed that microbial-specific indoles regulated …
[PDF][PDF] Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A
…, J Falck, T Schroeder, L Rönnstrand, KK Khanna… - Cancer cell, 2003 - cell.com
Chk1 kinase coordinates cell cycle progression and preserves genome integrity. Here, we
show that chemical or genetic ablation of human Chk1 triggered supraphysiological …
show that chemical or genetic ablation of human Chk1 triggered supraphysiological …
[HTML][HTML] A comprehensive review on current advances in peptide drug development and design
Protein–protein interactions (PPIs) execute many fundamental cellular functions and have
served as prime drug targets over the last two decades. Interfering intracellular PPIs with small …
served as prime drug targets over the last two decades. Interfering intracellular PPIs with small …