Soft matter models of developing tissues and tumors

D Gonzalez-Rodriguez, K Guevorkian, S Douezan… - Science, 2012 - science.org
… In the method proposed by Guevorkian et al. (21), an aggregate is aspirated at constant
suction pressure into a micropipette of smaller diameter than that of the aggregate, and the …

Aspiration of biological viscoelastic drops

K Guevorkian, MJ Colbert, M Durth, S Dufour… - Physical review …, 2010 - APS
Spherical cellular aggregates are in vitro systems to study the physical and biophysical
properties of tissues. We present a novel approach to characterize the mechanical properties of …

Spreading dynamics and wetting transition of cellular aggregates

S Douezan, K Guevorkian, R Naouar… - Proceedings of the …, 2011 - National Acad Sciences
We study the spreading of spheroidal aggregates of cells, expressing a tunable level of E-cadherin
molecules, on glass substrates decorated with mixed fibronectin and polyethylene …

[PDF][PDF] A gradient of glycolytic activity coordinates FGF and Wnt signaling during elongation of the body axis in amniote embryos

…, F Xiong, E Karoly, J Chal, K Guevorkian… - Developmental cell, 2017 - cell.com
… (K and L) Enzymatic detection of relative lactate level (K) and relative ATP concentration (L)
in the posterior region of control 2-day-old chicken embryos and in embryos cultured in …

Mechanosensitive shivering of model tissues under controlled aspiration

K Guevorkian, D Gonzalez-Rodriguez… - Proceedings of the …, 2011 - National Acad Sciences
… By analogy with a viscoelastic liquid, we characterize the aggregate’s mechanical behavior
using a modified Maxwell model consisting of two springs of constants k 1 and k 2 and two …

Micropipette aspiration: A unique tool for exploring cell and tissue mechanics in vivo

K Guevorkian, JL Maître - Methods in cell biology, 2017 - Elsevier
Cell and tissue mechanical properties are paramount in controlling morphogenesis.
Microaspiration techniques allow measuring the absolute values of mechanical properties in space …

[PDF][PDF] Spreading dynamics of biomimetic actin cortices

M Murrell, LL Pontani, K Guevorkian, D Cuvelier… - Biophysical journal, 2011 - cell.com
Reconstituted systems mimicking cells are interesting tools for understanding the details of
cell behavior. Here, we use an experimental system that mimics cellular actin cortices, …

[PDF][PDF] Mechanics of biomimetic liposomes encapsulating an actin shell

K Guevorkian, J Manzi, LL Pontani, F Brochard-Wyart… - Biophysical journal, 2015 - cell.com
… 3 C, where k is obtained from each Lcross separately. We have also observed that the
elastic coefficient k does not … We first analyze k values for bulk liposomes. The distribution of …

Swimming Paramecium in magnetically simulated enhanced, reduced, and inverted gravity environments

K Guevorkian, JM Valles Jr - Proceedings of the National …, 2006 - National Acad Sciences
Earth's gravity exerts relatively weak forces in the range of 10–100 pN directly on cells in
biological systems. Nevertheless, it biases the orientation of swimming unicellular organisms, …

Rectified random cell motility as a mechanism for embryo elongation

I Regev, K Guevorkian, A Gupta, O Pourquié… - …, 2022 - journals.biologists.com
The body of vertebrate embryos forms by posterior elongation from a terminal growth zone
called the tail bud. The tail bud is a source of highly motile cells that eventually constitute the …