Haplotyping of human chromosomes is a prerequisite for cataloguing the full repertoire of
genetic variation. We present a microfluidics-based, linked-read sequencing technology that …

… The Proteinase K and RNaseA digestion was incubated for 30 min at 25 C. Genomic DNA
was purified using MagAttract Suspension G with Buffer MB, washed twice with Buffer MW1, …

Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology,
but the accuracy, sensitivity and reproducibility of ctDNA assays is poorly understood. Here …

Examining complete gene knockouts within a viable organism can inform on gene function.
We sequenced the exomes of 3222 British adults of Pakistani heritage with high parental …

… Second, Linked-Reads are produced by random k-mer amplification of the 50- to 100-kb
molecules present in the small partitions. As such, there are times when these molecules are …

Background Sample index cross-talk can result in false positive calls when massively parallel
sequencing (MPS) is used for sensitive applications such as low-frequency somatic variant …

… Strebel K.The envelope glycoprotein of human immunodeficiency virus type 2 enhances …
Kirkegaard K.Remodeling the endoplasmic reticulum by poliovirus infection and by individual …

The endoplasmic reticulum (ER) is organized in part by adapter proteins that nucleate the
formation of large protein complexes. Tetratricopeptide repeats (TPR) are well studied protein …

Background Oncopanel genomic testing, which identifies important somatic variants, is
increasingly common in medical practice and especially in clinical trials. Currently, there is a …

We have used a new platform from 10X Genomics to obtain ultra-deep and long-range
exome sequencing data from 1ng of cancer cell line DNA. While traditional Whole Exome …