Solute carrier (SLC) transporters — a family of more than 300 membrane-bound proteins that
facilitate the transport of a wide array of substrates across biological membranes — have …

… MATE1 and MATE2-K are expressed in the apical membrane of the renal proximal tubule
cells, and studies in healthy individuals suggest that they contribute to the renal excretion of …

The SLC28 family consists of three subtypes of sodium-dependent, concentrative nucleoside
transporters, CNT1, CNT2, and CNT3 (SLC28A1, SLC28A2, and SLC28A3, respectively), …

… To obtain the K m and V max in the kinetic studies, the data were fit to the Michaelis-Menten
equation: V = V max × S/(K m +S), where V max is the maximum transport rate, K m is the …

The goal of this study was to determine the effects of genetic variation in the organic cation
transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty …

Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have
similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The …

… in the specified Na + and K + buffer were measured with the use of standard microelectrode
techniques (16). In the pH-dependency studies, the K + buffers were used at various pH …

Statins reduce cholesterol, prevent cardiovascular disease, and are among the most
commonly prescribed medications in the world. Statin‐associated musculoskeletal symptoms (…

Objectives There is increasing evidence that polymorphism of the ABCB1 (MDR1) gene
contributes to interindividual variability in bioavailability and tissue distribution of P-glycoprotein …

Serious adverse drug reactions (SADRs) are a major cause of morbidity and mortality
worldwide. Some SADRs may be predictable, based upon a drug's pharmacodynamic and …