The transition from castration-resistant prostate adenocarcinoma (CRPC) to neuroendocrine
prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance. …

Over the past decade, the rate of drug attrition due to clinical trial failures has risen substantially.
Unfortunately it is difficult to identify compounds that have unfavorable toxicity properties …

Drug target identification is a crucial step in development, yet is also among the most
complex. To address this, we develop BANDIT, a Bayesian machine-learning approach that …

CRISPR loci are a cluster of repeats separated by short "spacer" sequences derived from
prokaryotic viruses and plasmids that determine the targets of the host's CRISPR-Cas immune …

A promising alternative to address the problem of acquired drug resistance is to rely on
combination therapies. Identification of the right combinations is often accomplished through trial …

The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc
cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The lack of appropriate neutralizing antibodies …

… Gayvert et al. present a broadly applicable systems biology method for identifying small
molecules and drugs that modulate transcription factor activity. They identified dexamethasone …

… k years, where k varies from 3 to 14. We find that ENCAPP performs consistently well for all
values of k (… if she does not have metastases for > = k years, where k varies from 3 to 10. Here …

Understanding the adaptation of SARS-CoV-2 is critical for the development of effective
treatments against this exceptionally successful human pathogen. To predict the emergence of …

Elucidating the molecular basis of human cancers is an extremely complex and challenging
task. A wide variety of computational tools and experimental techniques have been used to …