… MDCK cells were a gift from K. Mostov and were grown in MEM, 5% FBS, penicillin and
streptomycin. To create MDCK lines stably expressing wild-type Smo or CLDSmo, the cells were …

Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are
autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and …

Mutations affecting ciliary components cause ciliopathies. As described here, we investigated
Tectonic1 (Tctn1), a regulator of mouse Hedgehog signaling, and found that it is essential …

Primary cilia are microtubule-based organelles involved in signal transduction and project
from the surface of most vertebrate cells 1 . Proteins that can localize to the cilium, for example…

Protein kinase C (PKC) regulates activation of the Raf-1 signaling cascade by growth factors,
but the mechanism by which this occurs has not been elucidated. Here we report that one …

▪ Abstract Topoisomerases are enzymes that use DNA strand scission, manipulation, and
rejoining activities to directly modulate DNA topology. These actions provide a powerful means …

This article addresses anthropology's engagement with the emerging discipline of global
health. We develop a definition for global health and then present four principal contributions of …

Nearly every ciliated organism possesses three B9 domain-containing proteins: MKS1, B9D1,
and B9D2. Mutations in human MKS1 cause Meckel syndrome (MKS), a severe ciliopathy …

In several neuronal cell systems, fibroblast-derived growth factor (FGF) and nerve growth
factor (NGF) act as neurogenic agents, whereas epidermal growth factor (EGF) acts as a …

Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged
in late 2019 and spread globally, prompting an international effort to accelerate development …