Background Artemisinin-based combination therapies are the recommended first-line treatments
of falciparum malaria in all countries with endemic disease. There are recent concerns …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia
and now poses a threat to the control and elimination of malaria. Mapping the geographic …

… We ran the algorithm for multiple values of K ≥ 2. To avoid fitting to local minima, for each
K we ran the algorithm 50 times with different random seeds and assessed the distributions of …

… III PI3-Kinase kit from Echelon Biosciences (K-3000) following the manufacturer’s instructions.
… ) using Echelon PI3P Mass ELISA Kit (K-3300) following the manufacturer’s instructions. …

The emergence of artemisinin resistance is a major obstacle to the global malaria
eradication/elimination programs. Artemisinin is a very fast-acting antimalarial drug and is the most …

Malaria is one of the most important tropical infectious diseases with an estimated incidence
of 300-500 million clinical cases worldwide each year and a mortality of between one and …

… PfHRP2 (C̄ 1 ) produced in the previous cycle will be C̄ 0 /M , and because of the exponential
decline described by k, the average amount left in the next cycle will be e −k (C̄ 0 /M) . …

… per synonymous site (K S ) compared with the number of nonsynonymous substitutions
per nonsynonymous site (K N ) (10) did not deviate from neutral expectations (K S >K N ; P < …

Indirect clinical measures assessing anti-malarial drug transmission-blocking activity in
falciparum malaria include measurement of the duration of gametocytaemia, the rate of …

Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated with …