Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

We present a DNA library preparation method that has allowed us to reconstruct a high-coverage
(30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The quality …

… In contrast, when there are K discrete populations sampled, one expects discrete clusters
to be separated out along K - 1 of the top PCs 8 . In our analysis, neither the first two PCs, nor …

… Varying the number of presumed ancestral populations (K) within … levels of K, we observed
clusters that identify single breeds as closed endogamous breeding units. For example, at K = …

Advances in genome technology have facilitated a new understanding of the historical and
genetic processes crucial to rapid phenotypic evolution under domestication 1 , 2 . To …

… We use the supervised algorithm for K ¼ 6, with 9,694 reference individuals representing
the six aforementioned populations. We ran ADMIXTURE on 269,229 autosomal markers after …

… We thank K. King for her work in managing and preparing the POPRES data. We thank
JD Degenhardt for helpful discussions and suggestions throughout the project, and KE …

… Interestingly, at K = 7, we were able to capture signals of continental substructure such as
a Southwest to Northeast gradient in Europe and a Native American component that is absent …

Technological and scientific advances, stemming in large part from the Human Genome and
HapMap projects, have made large-scale, genome-wide investigations feasible and cost …

According to historical records of transatlantic slavery, traders forcibly deported an estimated
12.5 million people from ports along the Atlantic coastline of Africa between the 16th and …