User profiles for K. V. Severinov

Konstantin Severinov

Verified email at waksman.rutgers.edu
Cited by 30867

[HTML][HTML] Microbial arsenal of antiviral defenses–part I

AB Isaev, OS Musharova, KV Severinov - Biochemistry (Moscow), 2021 - Springer
Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review
we will also consider viruses that infect Archaea). Constant threat of phage infection is a …

[HTML][HTML] Microbial arsenal of antiviral defenses. Part II

AB Isaev, OS Musharova, KV Severinov - Biochemistry (Moscow), 2021 - Springer
Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review
we will also consider viruses that infect Archaea). The constant threat of phage infection is a …

[HTML][HTML] Type III CRISPR-Cas systems: deciphering the most complex prokaryotic immune system

…, KA Karneyeva, DN Artamonova, KV Severinov - Biochemistry …, 2021 - Springer
The emergence and persistence of selfish genetic elements is an intrinsic feature of all living
systems. Cellular organisms have evolved a plethora of elaborate defense systems that …

Regulation of elongation factor‐2 by multisite phosphorylation

…, NT PRICE, KV SEVERINOV… - European journal of …, 1993 - Wiley Online Library
We have studied the phosphorylation of protein synthesis elongation factor eEF‐2, the
effects of phosphorylation on its activity and dephosphorylation of phosphorylated eEF‐2 by …

The CRISPR spacer space is dominated by sequences from species-specific mobilomes

…, V Sitnik, KS Makarova, YI Wolf, KV Severinov… - MBio, 2017 - Am Soc Microbiol
Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein (CRISPR-Cas)
systems store the memory of past encounters with foreign DNA in unique …

Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis

…, KS Makarova, YI Wolf, KV Severinov… - Proceedings of the …, 2018 - National Acad Sciences
The CRISPR-Cas systems of bacterial and archaeal adaptive immunity consist of direct
repeat arrays separated by unique spacers and multiple CRISPR-associated (cas) genes …

Identification of the phosphorylation sites in elongation factor-2 from rabbit reticulocytes

NT Price, NT Redpath, KV Severinov, DG Campbell… - FEBS letters, 1991 - Elsevier
The sites in eukaryotic elongation factor eEF-2 phosphorylated by the Ca 2+ /calmodulin-dependent
eEF-2 kinase in vitro have been identified. The kinase catalysed the rapid …

Ultrahigh-throughput functional profiling of microbiota communities

…, EN Ilina, VV Vlasov, KV Severinov… - Proceedings of the …, 2018 - National Acad Sciences
Microbiome spectra serve as critical clues to elucidate the evolutionary biology pathways,
potential pathologies, and even behavioral patterns of the host organisms. Furthermore, exotic …

Structure and function of virion RNA polymerase of a crAss-like phage

…, N Yutin, KS Makarova, EV Koonin, KV Severinov… - Nature, 2021 - nature.com
CrAss-like phages are a recently described expansive group of viruses that includes the most
abundant virus in the human gut 1 , 2 – 3 . The genomes of all crAss-like phages encode a …

[HTML][HTML] Mapping CRISPR spaceromes reveals vast host-specific viromes of prokaryotes

…, YI Wolf, E Savitskaya, KV Severinov… - Communications …, 2020 - nature.com
CRISPR arrays contain spacers, some of which are homologous to genome segments of
viruses and other parasitic genetic elements and are employed as portion of guide RNAs to …