User profiles for K. S. Small
Kerrin SmallProfessor, King's College London Verified email at kcl.ac.uk Cited by 26325 |
[HTML][HTML] Methodological challenges of genome-wide association analysis in Africa
… Two further observations support this approach: malaria has been a strong force for selection
on the human genome, and only a small fraction of host genetic resistance to malaria is …
on the human genome, and only a small fraction of host genetic resistance to malaria is …
Human metabolic individuality in biomedical and pharmaceutical research
… The combination of SNP and trait that yielded the smallest P value in this meta-analysis
was finally selected for each locus. To account for multiple testing, we applied conservative …
was finally selected for each locus. To account for multiple testing, we applied conservative …
Mapping cis- and trans-regulatory effects across multiple tissues in twins
… Given the large number of tests performed and the relatively small effect sizes of trans … to
be tissue dependent, had relatively small effect sizes and were associated with transcripts with …
be tissue dependent, had relatively small effect sizes and were associated with transcripts with …
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
…, A Rasheed, M Samuel, N Shah, AS Shera, KS Small… - Nature …, 2011 - nature.com
We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and …
[HTML][HTML] Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
… Our results suggest that in a small set of genes DNA methylation may be a candidate
mechanism of mediating not only environmental, but also genetic effects on age-related phenotypes…
mechanism of mediating not only environmental, but also genetic effects on age-related phenotypes…
The fecal metabolome as a functional readout of the gut microbiome
… To remove protein, dissociate small molecules bound to protein or trapped in the … samples:
a pooled sample generated from a small portion of each experimental sample of interest …
a pooled sample generated from a small portion of each experimental sample of interest …
[HTML][HTML] Genome-wide and fine-resolution association analysis of malaria in West Africa
… Using Wright's F ST across all autosomal SNPs, we found that differences between ethnic
groups accounted for a small fraction of genetic variation within the population as a whole (F …
groups accounted for a small fraction of genetic variation within the population as a whole (F …
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …
[PDF][PDF] Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements
…, M Sekowska, A Wilk, A Barrett, KS Small… - The American Journal of …, 2013 - cell.com
… most of the studies presented to date have been limited to either whole-blood-derived DNA
samples or targeted arrays of promoter regions (ie, Illumina 27K), which include only a small …
samples or targeted arrays of promoter regions (ie, Illumina 27K), which include only a small …
[HTML][HTML] Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Protein-coding genetic variants that strongly affect disease risk can yield relevant clues to
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …
disease pathogenesis. Here we report exome-sequencing analyses of 20,791 individuals with …