Postnatal tissue quiescence is thought to be a default state in the absence of a proliferative
stimulus such as injury. Although previous studies have demonstrated that certain embryonic …

Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical approach …

Accelerating cures for children with cancer remains an immediate challenge as a result of
extensive oncogenic heterogeneity between and within histologies, distinct molecular …

Long noncoding RNAs (lncRNAs) are thought to play important roles in regulating gene
transcription, but few have well-defined expression patterns or known biological functions during …

We developed an RNA-sequencing-based pipeline to discover differentially expressed cell-surface
molecules in neuroblastoma that meet criteria for optimal immunotherapeutic target …

Mitochondrial homeostasis depends on mitophagy, the programmed degradation of
mitochondria. Only a few proteins are known to participate in mitophagy. Here we develop a …

Background Somatic genetic testing is rapidly becoming the standard of care in many adult
and pediatric cancers. Previously, the standard approach was single-gene or focused …

Tumor-associated macrophages (TAMs) play an important role in tumor immunity and comprise
of subsets that have distinct phenotype, function, and ontology. Transcriptomic analyses …

High-risk neuroblastomas with hyperactivated RAS signaling escape the selective pressure
of MEK inhibition via YAP1-mediated transcriptional reprogramming and may be sensitive to …

Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but
cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. …