A class of small, non-coding transcripts called microRNAs (miRNAs) that provide a crucial and
pervasive layer of post-transcriptional gene regulation has recently emerged and become …

There is an urgent need to find effective presymptomatic Alzheimer’s disease (AD) treatments
that reduce the risk of AD symptoms or prevent them completely. It currently takes too …

MicroRNAs (miRNAs) are endogenously expressed noncoding RNAs that regulate mRNA
expression. In vertebrates, more distinct miRNAs are expressed in the brain than in any other …

MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate protein expression
by targeting the mRNA of protein-coding genes for either cleavage or repression of …

… We thank members of Kenneth Kosik laboratory for helpful discussions and comments on
the manuscript, and members of Jie Shen laboratory for help with PS1 KO mice. We are …

The detailed protein composition of the paired helical filaments (PHF) that accumulate in
human neurons in aging and Alzheimer disease is unknown. However, the identity of certain …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive accumulation in selected neurons of protein inclusions containing α-synuclein and …

MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an
important role in many developmental processes. We report here that expression of microRNA-…

Sponges are an ancient group of animals that diverged from other metazoans over 600 million
years ago. Here we present the draft genome sequence of Amphimedon queenslandica, …

MicroRNA dysregulation is observed in different types of cancer. MiR-21 up-regulation has
been reported for the majority of cancers profiled to date; however, knowledge is limited on …