Obesity is strongly correlated with type 2 diabetes mellitus, a common disorder of glucose and
lipid metabolism. Although adipocytes are critical in obesity, their role in diabetes has only …

Insulin resistance is necessary but not sufficient for the development of type 2 diabetes.
Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by …

Genetic variation drives phenotypic diversity and influences the predisposition to metabolic
disease. Here, we characterize the metabolic phenotypes of eight genetically distinct inbred …

Type 2 diabetes results from severe insulin resistance coupled with a failure of β cells to
compensate by secreting sufficient insulin. Multiple genetic loci are involved in the development …

Coordinated regulation of gene expression levels across a series of experimental
conditions provides valuable information about the functions of correlated transcripts. The …

The lipogenic gene stearoyl-CoA desaturase (SCD)1 appears to be a promising new target
for obesity-related diabetes, as mice deficient in this enzyme are resistant to diet- and leptin …

The mammalian intestinal tract contains a complex microbial ecosystem with many lysogens,
which are bacteria containing dormant phages (prophages) inserted within their genomes. …

The molecular bases of how host genetic variation impacts the gut microbiome remain
largely unknown. Here we used a genetically diverse mouse population and applied systems …

Obesity is a strong risk factor for the development of type 2 diabetes. We have previously
reported that in adipose tissue of obese (ob/ob) mice, the expression of adipogenic genes is …

The microbial communities that inhabit the distal gut of humans and other mammals exhibit
large inter-individual variation. While host genetics is a known factor that influences gut …