The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound
chemokine receptor crucial for the infection of red blood cells by Plasmodium vivax, a …

We present three linkage-disequilibrium (LD)-based recombination maps generated using
whole-genome sequence data from 10 Nigerian chimpanzees, 13 bonobos, and 15 western …

The purpose of this randomised single blinded study was to determine the optimal size of
laryngeal mask airway in the normal adult population, to test the validity of the current selection …

Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in
humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD…

Although population-level genomic sequence data have been gathered extensively for
humans, similar data from our closest living relatives are just beginning to emerge. Examination …

Hypersensitivity reactions to drugs are often unpredictable and can be life threatening,
underscoring a need for understanding their underlying mechanisms and risk factors. The extent …

Native American genetic variation remains underrepresented in most catalogs of human
genome sequencing data. Previous genotyping efforts have revealed that Mexico’s Indigenous …

Estimating the genomic location and length of identical-by-descent (IBD) segments among
individuals is a crucial step in many genetic analyses. However, the exponential growth in the …

Background Alpha-1 antitrypsin deficiency (AATD) is an autosomal co-dominant condition
that predisposes to emphysema, cirrhosis, panniculitis, and vasculitis. Underrecognition has …

Genome-wide association studies (GWAS) have identified a number of risk loci for cutaneous
melanoma. Cutaneous melanoma shares overlapping genetic risk (genetic correlation) …