Background Gene set analysis (GSA) is a widely used strategy for gene expression data
analysis based on pathway knowledge. GSA focuses on sets of related genes and has …

Wnts comprise a family of secreted signaling proteins that regulate diverse developmental
processes. Activation of Wnt signaling by Wnt10b inhibits differentiation of preadipocytes and …

Bone marrow‐derived mesenchymal stem cells (MSCs) are multipotent progenitors that can
commit to osteoblast, chondrocyte, adipocyte, and several other lineages. The proper …

… Hankenson has received grant support and serves as a consultant for Synthes Biomaterials.
… Hankenson is supported primarily by non-profit extramural funding including grants from …

Mesenchymal precursor cells have the potential to differentiate into several cell types,
including adipocytes and osteoblasts. Activation of Wnt/β-catenin signaling shifts mesenchymal …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

Adult stem cells offer the potential to treat many diseases through a combination of ex vivo
genetic manipulation and autologous transplantation. Mesenchymal stem cells (MSCs, also …

Bones are constantly remodeled throughout life to maintain robust structure and function.
Dysfunctional remodeling can result in pathological conditions such as osteoporosis (bone loss…

… Hankenson has been an independent scientist since 2002, first at the University of Michigan,
and currently at the University of Pennsylvania. Dr. Hankenson has … Hankenson's laboratory …

To date, the delivery of signaling molecules for bone regeneration has focused primarily on
factors that directly affect the bone formation pathways (osteoinduction) or that serve to …