Single-cell genome sequencing has proven valuable for the detection of somatic variation,
particularly in the context of tumor evolution. Current technologies suffer from high library …

We present a highly scalable assay for whole-genome methylation profiling of single cells.
We use our approach, single-cell combinatorial indexing for methylation analysis (sci-MET), …

Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo
loss. We previously showed that human preimplantation embryos encapsulate missegregated …

Here we present a comprehensive map of the accessible chromatin landscape of the
mouse hippocampus at single-cell resolution. Substantial advances of this work include the …

High-throughput single-cell epigenomic assays can resolve cell type heterogeneity in complex
tissues, however, spatial orientation is lost. Here, we present single-cell combinatorial …

Abstract Development is a complex process that requires the precise modulation of
regulatory gene networks controlled through dynamic changes in the epigenome. Single-cell-omic …

Here we present a novel method: single-cell combinatorial indexing for methylation analysis
(sci-MET), which is the first highly scalable assay for whole genome methylation profiling of …

Chromosome Removal Via Cellular Fragmentation and Aneuploid Blastomere Exclusion in
Primate Embryos Page 1 1 Chromosome Removal Via Cellular Fragmentation and Aneuploid …

Aneuploidy that arises during meiosis and/or mitosis is a major contributor to early embryo
loss. We previously demonstrated that human preimplantation embryos encapsulate mis-…

Here we present a comprehensive map of the accessible chromatin landscape of the
mouse hippocampus at single-cell resolution. Substantial advances of this work include the …