Anatomy and physiology of the eye makes it a highly protected organ. Designing an effective
therapy for ocular diseases, especially for the posterior segment, has been considered as a …

Diffuse large B cell lymphoma (DLBCL), the most common lymphoid malignancy in adults,
is a clinically and genetically heterogeneous disease that is further classified into …

To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …

… and deleted markers and in each sample j. After randomizing sample assignments for each
… and and represent the numbers of amplified and deleted markers in sample j and step t. T …

A key mutational process in cancer is structural variation, in which rearrangements delete,
amplify or reorder genomic segments that range in size from kilobases to whole chromosomes …

The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…

New technologies and analysis methods are enabling genomic structural variants (SVs) to
be detected with ever-increasing accuracy, resolution and comprehensiveness. To help …

Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer (mCRPC),
but there have been few whole-genome sequencing (WGS) studies of this disease …

Ocular allergy is an inflammatory response of the conjunctival mucosa that also affects the
cornea and eyelids. Allergic conjunctivitis includes seasonal allergic conjunctivitis (SAC), …

About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …