User profiles for J. Upson

John W Upson

University of West Georgia
Verified email at westga.edu
Cited by 496

Lessons in effector and NLR biology of plant-microbe systems

…, HG Pennington, K Yoshida, JL Upson… - Molecular Plant …, 2018 - Am Phytopath Society
A diversity of plant-associated organisms secrete effectors—proteins and metabolites that
modulate plant physiology to favor host infection and colonization. However, effectors can also …

The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines

SJ Grille, A Bellacosa, J Upson, AJ Klein-Szanto… - Cancer research, 2003 - AACR
Epithelial-mesenchymal transition (EMT) is an important process during development and
oncogenesis by which epithelial cells acquire fibroblast-like properties and show reduced …

The coming of age of EvoMPMI: evolutionary molecular plant–microbe interactions across multiple timescales

JL Upson, EK Zess, A Białas, C Wu… - Current Opinion in Plant …, 2018 - Elsevier
Plant–microbe interactions are great model systems to study co-evolutionary dynamics across
multiple timescales. However, mechanistic research on plant–microbe interactions has …

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2

…, P Gao, W Wang, V Beljanski, JJ Upson… - … of Pharmacology and …, 2010 - ASPET
Sphingolipid-metabolizing enzymes control the dynamic balance of the cellular levels of
important bioactive lipids, including the apoptotic compound ceramide and the proliferative …

Antitumor activity of sphingosine kinase inhibitors

KJ French, JJ Upson, SN Keller, Y Zhuang… - … of Pharmacology and …, 2006 - ASPET
Sphingosine kinase (SK) is an oncogenic sphingolipid-metabolizing enzyme that catalyzes
the formation of the mitogenic second messenger sphingosine-1-phosphate (S1P) at the …

Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase

…, Y Zhuang, Z Xia, SN Keller, JJ Upson… - Digestive diseases and …, 2008 - Springer
A critical step in the mechanism of action of inflammatory cytokines is the stimulation of
sphingolipid metabolism, including activation of sphingosine kinase (SK), which produces the …

[HTML][HTML] Plant pathogens convergently evolved to counteract redundant nodes of an NLR immune receptor network

…, H Adachi, J Upson, AV Cruces, R Xie, J Skłenar… - PLoS …, 2021 - journals.plos.org
In plants, nucleotide-binding domain and leucine-rich repeat (NLR)-containing proteins can
form receptor networks to confer hypersensitive cell death and innate immunity. One class of …

Revisiting Hofstede's dimensions: Examining the cultural convergence of the United States and Japan

…, BJ Bergiel, JW Upson - American Journal of …, 2012 - na-businesspress.com
It has been over forty years since Hofstede’s groundbreaking study on cultural values. Since
then, there have been drastic changes to the global landscape influenced by political, …

Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis

CE Ducker, JJ Upson, KJ French, CD Smith - Molecular cancer research, 2005 - AACR
N-myristoyltransferases (NMT) add myristate to the NH 2 termini of certain proteins, thereby
regulating their localization and/or biological function. Using RNA interference, this study …

Competitor analysis and foothold moves

JW Upson, DJ Ketchen Jr, BL Connelly… - … of Management Journal, 2012 - journals.aom.org
A foothold is a small position that a firm intentionally establishes within a market in which it
does not yet compete. We extend theory on competitive dynamics to examine relationships …