In 1997, an International Expert Committee was convened to reexamine the classification
and diagnostic criteria of diabetes, which were based on the 1979 publication of the National …

Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases
many inflammatory mediators. The source of these mediators within adipose tissue is not clear…

Cardiovascular diseases (CVD) are a major cause of mortality in the world, although great
variability exists in the death rates in different regions of the world. In the developed countries …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

Background Type 2 diabetes mellitus is increasingly common, primarily because of increases
in the prevalence of a sedentary lifestyle and obesity. Whether type 2 diabetes can be …

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

ESC Guidelines 3039 administrative staff and by the referees and supervisory committees
of the two organizations. It is our hope that this huge effort has generated guidelines that will …

Background Isolated systolic hypertension occurs in about 15% of people aged 60 years or
older. In 1989, the European Working Party on High Blood Pressure in the Elderly …

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has
been a formidable challenge. Adopting a genome-wide association strategy, we genotyped …

Background The incidence of hematologic cancers increases with age. These cancers are
associated with recurrent somatic mutations in specific genes. We hypothesized that such …