Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …
architecture or its genetic relationship with other disorders. To discover loci associated …
[HTML][HTML] Genome-wide association study reveals two new risk loci for bipolar disorder
…, J Strohmaier, F Degenhardt, J Treutlein… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants involved …
association studies (GWAS) have robustly identified the first common genetic variants involved …
[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder
…, M Schwandt, F Streit, J Strohmaier… - The Lancet …, 2020 - thelancet.com
Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …
twin and family heritability about 50–70%) and is associated with negative …
[PDF][PDF] Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder
…, M Mattheisen, X Miró, J Strohmaier… - The American Journal of …, 2011 - cell.com
We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar
disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 …
disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 …
Complement genes contribute sex-biased vulnerability in diverse disorders
Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …
Adverse reactions to antidepressants
…, D Souery, A Placentino, J Strohmaier… - The British Journal of …, 2009 - cambridge.org
BackgroundAdverse drug reactions are important determinants of non-adherence to
antidepressant treatment but their assessment is complicated by overlap with depressive symptoms …
antidepressant treatment but their assessment is complicated by overlap with depressive symptoms …
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept
…, RE Straub, E Strengman, J Strohmaier… - Nature …, 2016 - nature.com
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …
function differ, on average, between people with schizophrenia and healthy individuals. As …
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
…, P Stopkova, F Streit, J Strohmaier… - Human molecular …, 2016 - academic.oup.com
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …