Biological insights from 108 schizophrenia-associated genetic loci

…, E Stogmann, RE Straub, E Strengman, J Strohmaier… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

…, S Steinberg, CA Stockmeier, F Streit, J Strohmaier… - Nature …, 2018 - nature.com
Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

…, M Schwandt, R Sherva, F Streit, J Strohmaier… - Nature …, 2018 - nature.com
Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic
architecture or its genetic relationship with other disorders. To discover loci associated …

[HTML][HTML] Genome-wide association study reveals two new risk loci for bipolar disorder

…, J Strohmaier, F Degenhardt, J Treutlein… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants involved …

[HTML][HTML] A large-scale genome-wide association study meta-analysis of cannabis use disorder

…, M Schwandt, F Streit, J Strohmaier… - The Lancet …, 2020 - thelancet.com
Background Variation in liability to cannabis use disorder has a strong genetic component (estimated
twin and family heritability about 50–70%) and is associated with negative …

[PDF][PDF] Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder

…, M Mattheisen, X Miró, J Strohmaier… - The American Journal of …, 2011 - cell.com
We conducted a genome-wide association study (GWAS) and a follow-up study of bipolar
disorder (BD), a common neuropsychiatric disorder. In the GWAS, we investigated 499,494 …

Complement genes contribute sex-biased vulnerability in diverse disorders

…, J Strohmaier, TS Stroup, M Subramaniam, J Suvisaari… - Nature, 2020 - nature.com
Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …

Adverse reactions to antidepressants

…, D Souery, A Placentino, J Strohmaier… - The British Journal of …, 2009 - cambridge.org
BackgroundAdverse drug reactions are important determinants of non-adherence to
antidepressant treatment but their assessment is complicated by overlap with depressive symptoms …

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

…, RE Straub, E Strengman, J Strohmaier… - Nature …, 2016 - nature.com
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …

Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder

…, P Stopkova, F Streit, J Strohmaier… - Human molecular …, 2016 - academic.oup.com
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …