Biopolymer stereocomplexes

J Slager, AJ Domb - Advanced drug delivery reviews, 2003 - Elsevier
A polymer stereocomplex is defined as a stereoselective interaction between two
complementing stereoregular polymers, that interlock and form a new composite, demonstrating …

[HTML][HTML] Hard-wired control of bacterial processes by chromosomal gene location

J Slager, JW Veening - Trends in microbiology, 2016 - cell.com
Bacterial processes, such as stress responses and cell differentiation, are controlled at many
different levels. While some factors, such as transcriptional regulation, are well appreciated, …

[HTML][HTML] iPSC-derived organ-on-a-chip models for personalized human genetics and pharmacogenomics studies

…, J Slager, C Wijmenga, IH Jonkers, V Kumar, J Fu… - Trends in Genetics, 2023 - cell.com
Genome-wide association studies (GWAS) have now correlated hundreds of genetic variants
with complex genetic diseases and drug efficacy. Functional characterization of these …

[PDF][PDF] Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin

J Slager, M Kjos, L Attaiech, JW Veening - Cell, 2014 - cell.com
Streptococcus pneumoniae (pneumococcus) kills nearly 1 million children annually, and the
emergence of antibiotic-resistant strains poses a serious threat to human health. Because …

Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor

T Sheskin, L Hanuš, J Slager, Z Vogel… - Journal of medicinal …, 1997 - ACS Publications
In order to establish the structural requirements for binding to the brain cannabinoid receptor
(CB 1 ), we have synthesized numerous fatty acid amides, ethanolamides, and some …

High‐throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae

…, C Gallay, M Kjos, A Domenech, J Slager… - Molecular systems …, 2017 - embopress.org
Genome‐wide screens have discovered a large set of essential genes in the opportunistic
human pathogen Streptococcus pneumoniae. However, the functions of many essential …

National partnership for maternal safety: consensus bundle on severe hypertension during pregnancy and the postpartum period

…, J Frost, CH Morton, C Ruhl, J Slager… - Obstetrics & …, 2017 - journals.lww.com
Complications arising from hypertensive disorders of pregnancy are among the leading
causes of preventable severe maternal morbidity and mortality. Timely and appropriate …

[HTML][HTML] Time-resolved dual RNA-seq reveals extensive rewiring of lung epithelial and pneumococcal transcriptomes during early infection

R Aprianto, J Slager, S Holsappel, JW Veening - Genome biology, 2016 - Springer
Background Streptococcus pneumoniae, the pneumococcus, is the main etiological agent
of pneumonia. Pneumococcal infection is initiated by bacterial adherence to lung epithelial …

Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39

J Slager, R Aprianto, JW Veening - Nucleic acids research, 2018 - academic.oup.com
A precise understanding of the genomic organization into transcriptional units and their
regulation is essential for our comprehension of opportunistic human pathogens and how they …

Enterovirus D68 receptor requirements unveiled by haploid genetics

…, LT Jae, Y Liu, H Guo, JJ Slager… - Proceedings of the …, 2016 - National Acad Sciences
Enterovirus D68 (EV-D68) is an emerging pathogen that can cause severe respiratory
disease and is associated with cases of paralysis, especially among children. Heretofore, …