The terminal step in cytokinesis, called abscission, requires resolution of the membrane
connection between two prospective daughter cells. Our previous studies demonstrated that the …

Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares
little homology with its siblings and has an essential role in centriole duplication. The turn-…

… Isomäki P, Luukkainen R, Saario R, Toivanen P, Punnonen J. Interleukin-10 functions as an
… Br J Rheumatol 1998;37:988–91. 51. Eskdale J, Gallagher G. A polymorphic dinucleotide …

Microtubule nucleation is the best known function of centrosomes. Centrosomal microtubule
nucleation is mediated primarily by γ tubulin ring complexes (γ TuRCs). However, little is …

The centrosome organizes microtubules by controlling nucleation and anchoring processes.
In mammalian cells, subdistal appendages of the mother centriole are major microtubule-…

Centrosomes nucleate microtubules and contribute to mitotic spindle organization and
function. They also participate in cytokinesis and cell cycle progression in ways that are poorly …

Microtubules and actin filaments are the two main cytoskeleton networks supporting intracellular
architecture and cell polarity. The centrosome nucleates and anchors microtubules and …

Multiplex ligation-dependent probe amplification (MLPA) is a recently described method for
detecting gross deletions or duplications of DNA sequences, aberrations which are …

We present the cytogenetic, molecular cytogenetic, and molecular genetic results on 20
unrelated patients with an interstitial duplication of the proximal long arm of chromosome 15. …

Centrosome duplication occurs once every cell cycle in a strictly controlled manner. Polo-like
kinase 4 (PLK4) is a key regulator of this process whose kinase activity is essential for …