The long-range movement of organelles, vesicles, and macromolecular complexes by
microtubule-based transport is crucial for cell growth and survival. The canonical view of …

Purpose The management of epilepsy in children is particularly challenging when seizures
are resistant to antiepileptic medications, or undergo many changes in seizure type over time…

The mechanisms that promote excitatory synapse formation and maturation have been
extensively studied. However, the molecular events that limit excitatory synapse development so …

Leucine-rich repeat kinase 2 (LRRK2) is the most commonly mutated gene in familial
Parkinson’s disease 1 and is also linked to its idiopathic form 2 . LRRK2 has been proposed to …

Although transcription factors that repress gene expression play critical roles in nervous
system development, their mechanism of action remains to be understood. Here, we report that …

Eukaryotic cells use microtubule-based intracellular transport for the delivery of many
subcellular cargos, including organelles. The canonical view of organelle transport is that …

… (I) Proximal gonad of a virgin animal; the compact nuclei of sperm (J) are visualized with
DAPI … We also thank J. Rothman for helpful comments on the manuscript, and T. Schedl, S. …

Angelman syndrome (AS) is a neurodevelopmental disorder arising from loss-of-function
mutations in the maternally inherited copy of the UBE3A gene, and is characterized by an …

Viruses interact directly with host proteins at nearly every step of their replication cycle. Such
molecular interactions can either benefit the host (eg., immune recognition) or the virus (eg., …

Intracellular bacterial pathogens gain entry to mammalian cells inside a vacuole derived
from the host membrane. Some of them escape the bacteria-containing vacuole (BCV) and …