Our understanding of gene expression has changed dramatically over the past decade,
largely catalysed by technological developments. High-throughput experiments — microarrays …

Many behaviors posing significant risks to public health are characterized by repeated
decisions to forego better long-term outcomes in the face of immediate temptations. Steeply …

Type 2 diabetes mellitus results from the interaction of environmental factors with a combination
of genetic variants, most of which were hitherto unknown. A systematic search for these …

Fructose-2,6-bisphosphate (Fru-2,6-P 2 ) regulates key reactions of the primary carbohydrate
metabolism in all eukaryotes. In plants, Fru-2,6-P 2 coordinates the photosynthetic carbon …

Genome-wide association studies have identified common variants that only partially explain
the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 …

The ArrayExpress Archive of Functional Genomics Data ( http://www.ebi.ac.uk/arrayexpress
) is one of three international functional genomics public data repositories, alongside the …

Using a genome-wide screen of 9.6 million genetic variants achieved through 1000 Genomes
Project imputation in 62,166 samples, we identify association to lipid traits in 93 loci, …

Motivation: A ubiquitous and fundamental step in high-throughput sequencing analysis is the
alignment (mapping) of the generated reads to a reference sequence. To accomplish this …

Several studies have shown that healthy individuals with fasting plasma glucose (FPG) levels
at the high end of the normal range have an increased risk of mortality. To identify genetic …

… a pair of samples S i and S j , we say that gene G … j , if G is expressed in S i and S j and the
ratio of the expression of I i to the expression of I j is at least x in S i and no more than 1/x in S j …