Genes and translated open reading frames (ORFs) that emerged de novo from previously
non-coding sequences provide species with opportunities for adaptation. When aberrantly …

The translatome can be defined as the sum of the RNA sequences that are translated into
proteins in the cell by the ribosomal machinery. Until recently, it was generally assumed that …

… Ruiz-Orera et al. analyzed RNA sequences collected from … Many of the lncRNAs that
Ruiz-Orera et al. investigated could … The combined findings of Ruiz-Orera et al. therefore suggest …

To the Editor—Ribosome profiling (Ribo-seq) has extended our understanding of the
translational ‘vocabulary’of the human genome, uncovering thousands of open reading frames (…

Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …

High throughput RNA sequencing techniques have revealed that a large fraction of the
genome is transcribed into long non-coding RNAs (lncRNAs). Unlike canonical protein-coding …

All species continuously evolve short open reading frames (sORFs) that can be templated for
protein synthesis and may provide raw materials for evolutionary adaptation. We analyzed …

Background Genomic studies of endangered species provide insights into their evolution and
demographic history, reveal patterns of genomic erosion that might limit their viability, and …

The birth of new genes is an important motor of evolutionary innovation. Whereas many new
genes arise by gene duplication, others originate at genomic regions that did not contain …

… Ruiz-Orera, J. et al. Origins of de novo genes in human and chimpanzee. … & Masel, J. Young
genes are highly disordered as predicted by the preadaptation hypothesis … Jorge Ruiz-Orera …