Evidence is strengthening for the morphological evaluation of tumor infiltrating lymphocytes (TILs)
in breast cancer. Herein, the concepts for TILs assessment are laid out by pathologists …

Triple-negative breast cancer, so called because it lacks expression of the estrogen receptor,
progesterone receptor, and HER2, is often, but not always, a basal-like breast cancer. This …

Next-generation sequencing (NGS) allows sequencing of a high number of nucleotides in a
short time frame at an affordable cost. While this technology has been widely implemented, …

All cancers carry somatic mutations in their genomes. A subset, known as driver mutations,
confer clonal selective advantage on cancer cells and are causally implicated in oncogenesis …

We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the
presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive RAS-dependent …

This review updates and consolidates evidence on the safety of transcranial Direct Current
Stimulation (tDCS). Safety is here operationally defined by, and limited to, the absence of …

Motor skills can take weeks to months to acquire and can diminish over time in the absence
of continued practice. Thus, strategies that enhance skill acquisition or retention are of great …

Background Cutaneous squamous-cell carcinomas and keratoacanthomas are common
findings in patients treated with BRAF inhibitors. Methods We performed a molecular analysis to …

We propose a data mining approach to predict human wine taste preferences that is based
on easily available analytical tests at the certification step. A large dataset (when compared …

Breast cancer is a heterogeneous disease with varied morphological appearances, molecular
features, behavior, and response to therapy. Current routine clinical management of …