DNA organization and dynamics profoundly affect many biological processes such as gene
regulation and DNA repair. In this review, we present the latest studies on DNA mobility in …

Homologous recombination, an essential process for preserving genomic integrity, uses
intact homologous sequences to repair broken chromosomes. To explore the mechanism of …

Understanding the plasticity of genomes has been greatly aided by assays for recombination,
repair and mutagenesis. These assays have been developed in microbial systems that …

A number of studies across different model systems revealed that chromatin undergoes
significant changes in dynamics in response to DNA damage. These include local motion …

Homologous recombination (HR) is a major pathway to repair DNA double-strand breaks (DSB).
HR uses an undamaged homologous DNA sequence as a template for copying the …

In response to double strand breaks (DSB), repair proteins accumulate at damaged sites,
forming membrane-less sub-compartments or foci. Here we explored the physical nature of …

DNA replication is a challenge for the faithful transmission of parental information to daughter
cells, as both DNA and chromatin organization must be duplicated. Replication stress …

The dynamic organization of genes inside the nucleus is an important determinant for their
function. Using fast DNA tracking microscopy in Saccharomyces cerevisiae cells and …

In response to DNA double strand breaks (DSB), repair proteins accumulate at damaged
sites, forming membrane-less condensates or “foci”. The formation of these foci and their …

The spatial organization of complex biochemical reactions is essential for the regulation of
cellular processes. Membrane-less structures called foci containing high concentrations of …