User profiles for J. Marko

John F. Marko

Professor, Molecular Biosciences and Physics & Astronomy, Northwestern University
Verified email at northwestern.edu
Cited by 23117

How do site‐specific DNA‐binding proteins find their targets?

SE Halford, JF Marko - Nucleic acids research, 2004 - academic.oup.com
Essentially all the biological functions of DNA depend on site‐specific DNA‐binding proteins
finding their targets, and therefore ‘searching’ through megabases of non‐target DNA. In …

Chromatin's physical properties shape the nucleus and its functions

AD Stephens, EJ Banigan, JF Marko - Current opinion in cell biology, 2019 - Elsevier
The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains
nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton. …

From the radiologic pathology archives: Adrenal tumors and tumor-like conditions in the adult: radiologic-pathologic correlation

GE Lattin Jr, ED Sturgill, CA Tujo, J Marko… - Radiographics, 2014 - pubs.rsna.org
Advanced imaging often reveals adrenal tumors and tumor-like conditions in both symptomatic
and asymptomatic patients. When adrenal disease is clinically suspected, cross-sectional …

Stretching dna

JF Marko, ED Siggia - Macromolecules, 1995 - ACS Publications
A statistical mechanical treatment of the wormlike chain model (WLC) isused to analyze
experiments in which double-stranded DNA, tethered at one end, is stretched by a force …

Entropic elasticity of λ-phage DNA

C Bustamante, JF Marko, ED Siggia, S Smith - Science, 1994 - science.org
20. Rat T9 cells were transfected by the calcium phosphate precipitation method with 1 jig of
pCMVEN10 complementary DNA (cDNA)(19) and 0.1 jig of pSV2neo (neomycin resistance …

[PDF][PDF] Interphase chromosomes undergo constrained diffusional motion in living cells

WF Marshall, A Straight, JF Marko, J Swedlow… - Current Biology, 1997 - cell.com
Background: Structural studies of fixed cells have revealed that interphase chromosomes are
highly organized into specific arrangements in the nucleus, and have led to a picture of the …

Statistical mechanics of supercoiled DNA

JF Marko, ED Siggia - Physical Review E, 1995 - APS
The two strands of a closed circular DNA molecule possess as a topological invariant their
linking number. This property, combined with an appreciable twist elastic constant, causes the …

Self-organization of domain structures by DNA-loop-extruding enzymes

E Alipour, JF Marko - Nucleic acids research, 2012 - academic.oup.com
The long chromosomal DNAs of cells are organized into loop domains much larger in size
than individual DNA-binding enzymes, presenting the question of how formation of such …

Prostate cancer: interobserver agreement and accuracy with the revised prostate imaging reporting and data system at multiparametric MR imaging

BG Muller, JH Shih, S Sankineni, J Marko… - Radiology, 2015 - pubs.rsna.org
Purpose To evaluate accuracy and interobserver variability with the use of the Prostate
Imaging Reporting and Data System (PI-RADS) version 2.0 for detection of prostate cancer at …

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

…, SA Adam, RD Goldman, JF Marko - Molecular biology of …, 2017 - Am Soc Cell Biol
The cell nucleus must continually resist and respond to intercellular and intracellular mechanical
forces to transduce mechanical signals and maintain proper genome organization and …