Neuroblastoma, an embryonal cancer of the autonomic nervous system, is the most
common cancer diagnosed during the first year of life. Although neuroblastoma accounts for …

PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm
in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic …

Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors that are
usually benign, but which may also present as or develop into a malignancy. Predicting such …

Neuroblastoma is a childhood cancer that can be inherited, but the genetic aetiology is largely
unknown. Here we show that germline mutations in the anaplastic lymphoma kinase (ALK…

Background Preclinical and preliminary clinical data indicate that ch14.18, a monoclonal
antibody against the tumor-associated disialoganglioside GD2, has activity against …

Neuroblastoma is a malignancy of the developing sympathetic nervous system that often
presents with widespread metastatic disease, resulting in survival rates of less than 50%. To …

Familial platelet disorder with predisposition to acute myelogenous leukaemia (FPD/AML,
MIM 601399) is an autosomal dominant disorder characterized by qualitative and quantitative …

The CD19 antigen, expressed on most B-cell acute lymphoblastic leukemias (B-ALL), can
be targeted with chimeric antigen receptor–armed T cells (CART-19), but relapses with …

Background Various human cancers have ALK gene translocations, amplifications, or
oncogenic mutations, such as anaplastic large-cell lymphoma, inflammatory myofibroblastic …

We present an extensive assessment of mutation burden through sequencing analysis of >81,000
tumors from pediatric and adult patients, including tumors with hypermutation caused …