Urban living in built environments, combined with the use of processed water and food, may
not provide the microbial stimulation necessary for a balanced development of immune …

… Höglund P, Auranen M, Socha J, Popinska K, Nazer H, Rajaram U, Holmberg C, de la
Chapelle A, Kere J. 1998a. Genetic background of congenital chloride diarrhea in high frequency …

(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions FC,
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …

Among complex disorders, those concerning neuropsychiatric phenotypes involve particular
challenges compared to disorders with more easily distinguished clinical signs and …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Epigenetic mechanisms integrate genetic and environmental causes of disease, but
comprehensive genome-wide analyses of epigenetic modifications have not yet demonstrated …

… Zonana, J. et al. High resolution mapping of the X-linked hypohidrotic ectodermal dysplasia
… Kere, J. etal. Anhidrotic ectodermal dysplasia gene region cloned in yeast artificial …

TREX1 acts in concert with the SET complex in granzyme A–mediated apoptosis, and
mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus. Here, we …

Methylation of cytosines at CpG sites is a common epigenetic DNA modification that can be
measured by a large number of methods, now even in a genome-wide manner for hundreds …