Cellular barcoding is a technique in which individual cells are labeled with unique nucleic
acid sequences, termed barcodes, so that they can be tracked through space and time. …

The cerebellum is a key player in many brain functions and a major topic of neuroscience
research. However, the cerebellar nuclei (CN), the main output structures of the cerebellum, …

Sleep quality declines with age; however, the underlying mechanisms remain elusive. We
found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation …

Neurons transmit information to distant brain regions via long-range axonal projections. In
the mouse, area-to-area connections have only been systematically mapped using bulk …

… N j of molecules at cycle j. Assuming that the probability of template switching following a
collision is s 0 and s 0 ≪ 1/N j , then the total number S j of template switches on cycle j is …

… i,j representing the absolute counts of barcode i in area j as previously described 30 . We
de-multiplexed the sequencing results, extracted the absolute counts of each barcode in each …

INTRODUCTION The brains of extant animals have evolved over hundreds of millions of
years from simple circuits. Cell types diversified, connections elaborated, and new brain …

Understanding neural circuits requires deciphering interactions among myriad cell types
defined by spatial organization, connectivity, gene expression, and other properties. Resolving …

In most sensory modalities, neuronal connectivity reflects behaviorally relevant stimulus
features, such as spatial location, orientation, and sound frequency. By contrast, the prevailing …

As acquiring bigger data becomes easier in experimental brain science, computational and
statistical brain science must achieve similar advances to fully capitalize on these data. …