[PDF][PDF] Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma

…, J Kaplinsky, I Peneva, A Frangou, PF Xie, J Chang… - Cancer Cell, 2023 - cell.com
For inoperable esophageal adenocarcinoma (EAC), identifying patients likely to benefit from
recently approved immunochemotherapy (ICI+CTX) treatments remains a key challenge. …

[HTML][HTML] Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples

J Kaplinsky, R Arnaout - Nature communications, 2016 - nature.com
The diversity of an organism’s B- and T-cell repertoires is both clinically important and a key
measure of immunological complexity. However, diversity is hard to estimate by current …

A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection

A Salehi-Reyhani, J Kaplinsky, E Burgin, M Novakova… - Lab on a Chip, 2011 - pubs.rsc.org
We have developed a generic platform to undertake the analysis of protein copy number
from single cells. The approach described here is ‘all-optical’ whereby single cells are …

Some like it hot, some like it warm: phenotyping to explore thermotolerance diversity

CH Yeh, NJ Kaplinsky, C Hu, Y Charng - Plant Science, 2012 - Elsevier
Plants have evolved overlapping but distinct cellular responses to different aspects of high
temperature stress. These responses include basal thermotolerance, short- and long-term …

Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells

J Kaplinsky, A Li, A Sun, M Coffre… - Proceedings of the …, 2014 - National Acad Sciences
… In contrast, we show that differential V H and J H gene segment choice contribute only
marginally to trends in CDR3 length and charge, consistent with their smaller contributions to the …

[HTML][HTML] Signatures of T cell immunity revealed using sequence similarity with TCRDivER algorithm

M Vujović, P Marcatili, B Chain, J Kaplinsky… - Communications …, 2023 - nature.com
Abstract Changes in the T cell receptor (TCR) repertoires have become important markers for
monitoring disease or therapy progression. With the rise of immunotherapy usage in cancer…

[HTML][HTML] T cell receptor sequence clustering and antigen specificity

…, B Chain, TL Andresen, J Kaplinsky… - Computational and …, 2020 - Elsevier
… This similarity comes from V and J genes shared across TCRs and the nature of V(D) J
recombination which introduces most sequence variability in the junctions between the individual …

Biomimicry versus humanism

J Kaplinsky - Architectural Design, 2006 - Wiley Online Library
Joe Kaplinsky takes issue with ‘biomimicry’ and the idea that nature rather than mechanical
solutions is the key to unlocking architecture. He argues that biological language and …

Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure

SV Perrone, EJ Kaplinsky - International journal of cardiology, 2005 - Elsevier
The clinician's primary objective in treating a patient with decompensated heart failure is rapid
and effective stabilization. This goal often is achieved through the use of inotropic support. …

SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation

J Rizk, J Kaplinsky, R Agerholm, D Kadekar, F Ivars… - Science …, 2019 - science.org
Second mitochondria-derived activator of caspase (SMAC) mimetics (SMs) are selective
antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-κB …