[PDF][PDF] Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma
For inoperable esophageal adenocarcinoma (EAC), identifying patients likely to benefit from
recently approved immunochemotherapy (ICI+CTX) treatments remains a key challenge. …
recently approved immunochemotherapy (ICI+CTX) treatments remains a key challenge. …
[HTML][HTML] Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples
J Kaplinsky, R Arnaout - Nature communications, 2016 - nature.com
The diversity of an organism’s B- and T-cell repertoires is both clinically important and a key
measure of immunological complexity. However, diversity is hard to estimate by current …
measure of immunological complexity. However, diversity is hard to estimate by current …
A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection
A Salehi-Reyhani, J Kaplinsky, E Burgin, M Novakova… - Lab on a Chip, 2011 - pubs.rsc.org
We have developed a generic platform to undertake the analysis of protein copy number
from single cells. The approach described here is ‘all-optical’ whereby single cells are …
from single cells. The approach described here is ‘all-optical’ whereby single cells are …
Some like it hot, some like it warm: phenotyping to explore thermotolerance diversity
CH Yeh, NJ Kaplinsky, C Hu, Y Charng - Plant Science, 2012 - Elsevier
Plants have evolved overlapping but distinct cellular responses to different aspects of high
temperature stress. These responses include basal thermotolerance, short- and long-term …
temperature stress. These responses include basal thermotolerance, short- and long-term …
Antibody repertoire deep sequencing reveals antigen-independent selection in maturing B cells
J Kaplinsky, A Li, A Sun, M Coffre… - Proceedings of the …, 2014 - National Acad Sciences
… In contrast, we show that differential V H and J H gene segment choice contribute only
marginally to trends in CDR3 length and charge, consistent with their smaller contributions to the …
marginally to trends in CDR3 length and charge, consistent with their smaller contributions to the …
[HTML][HTML] Signatures of T cell immunity revealed using sequence similarity with TCRDivER algorithm
Abstract Changes in the T cell receptor (TCR) repertoires have become important markers for
monitoring disease or therapy progression. With the rise of immunotherapy usage in cancer…
monitoring disease or therapy progression. With the rise of immunotherapy usage in cancer…
[HTML][HTML] T cell receptor sequence clustering and antigen specificity
…, B Chain, TL Andresen, J Kaplinsky… - Computational and …, 2020 - Elsevier
… This similarity comes from V and J genes shared across TCRs and the nature of V(D) J
recombination which introduces most sequence variability in the junctions between the individual …
recombination which introduces most sequence variability in the junctions between the individual …
Biomimicry versus humanism
J Kaplinsky - Architectural Design, 2006 - Wiley Online Library
Joe Kaplinsky takes issue with ‘biomimicry’ and the idea that nature rather than mechanical
solutions is the key to unlocking architecture. He argues that biological language and …
solutions is the key to unlocking architecture. He argues that biological language and …
Calcium sensitizer agents: a new class of inotropic agents in the treatment of decompensated heart failure
SV Perrone, EJ Kaplinsky - International journal of cardiology, 2005 - Elsevier
The clinician's primary objective in treating a patient with decompensated heart failure is rapid
and effective stabilization. This goal often is achieved through the use of inotropic support. …
and effective stabilization. This goal often is achieved through the use of inotropic support. …
SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation
J Rizk, J Kaplinsky, R Agerholm, D Kadekar, F Ivars… - Science …, 2019 - science.org
Second mitochondria-derived activator of caspase (SMAC) mimetics (SMs) are selective
antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-κB …
antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-κB …