User profiles for J. Gutierrez-Achury
Javier Gutierrez-AchuryChief Scientific Officer - Indigo Technologies Verified email at indigo.tech Cited by 5550 |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease 1 ,
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
The genetic architectures of common, complex diseases are largely uncharacterized. We
modeled the genetic architecture underlying genome-wide association study (GWAS) data for …
modeled the genetic architecture underlying genome-wide association study (GWAS) data for …
Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …
fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation 1 , 2 , …
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease
…, EM Schlicht, JZ Liu, T Shah, J Gutierrez-Achury… - Nature …, 2017 - nature.com
Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct
destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook …
destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook …
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on
a log-additive scale. Here we speculated that differences in autoantigen-binding repertoires …
a log-additive scale. Here we speculated that differences in autoantigen-binding repertoires …
Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
… , j indicates the specific allele being tested and x i,j corresponds to the dosage imputed or
genotyped for allele j … We thank J. Senior for carefully reading the manuscript and C. Gonzalez-…
genotyped for allele j … We thank J. Senior for carefully reading the manuscript and C. Gonzalez-…
Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants
Background The majority of coeliac disease (CD) patients are not being properly diagnosed
and therefore remain untreated, leading to a greater risk of developing CD-associated …
and therefore remain untreated, leading to a greater risk of developing CD-associated …
Identification of multiple independent susceptibility loci in the HLA region in Behcet's disease
…, C Salvarani, B Casali, I Kötter, J Gutierrez-Achury… - Nature …, 2013 - nature.com
Behçet's disease is an inflammatory disease characterized by recurrent oral and genital
ulcers and significant organ involvement. Localizing the genetic association between HLA-B*51 …
ulcers and significant organ involvement. Localizing the genetic association between HLA-B*51 …
[HTML][HTML] Improved imputation quality of low-frequency and rare variants in European samples using the 'Genome of The Netherlands'
…, J Van Setten, J Gutierrez-Achury… - European Journal of …, 2014 - nature.com
Although genome-wide association studies (GWAS) have identified many common variants
associated with complex traits, low-frequency and rare variants have not been interrogated …
associated with complex traits, low-frequency and rare variants have not been interrogated …
[HTML][HTML] Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations
Background In recent years, research has consistently proven the occurrence of genetic
overlap across autoimmune diseases, which supports the existence of common pathogenic …
overlap across autoimmune diseases, which supports the existence of common pathogenic …