User profiles for J. Guinney
Justin GuinneyTempus Verified email at tempus.com Cited by 30750 |
Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer
Critical driver genomic events in colorectal cancer have been shown to affect the response
to targeted agents that were initially developed under the 'one gene, one drug' paradigm of …
to targeted agents that were initially developed under the 'one gene, one drug' paradigm of …
[PDF][PDF] The human tumor atlas network: charting tumor transitions across space and time at single-cell resolution
Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …
[PDF][PDF] The immune landscape of cancer
…, H Shen, TK Choueiri, JN Weinstein, J Guinney, J Saltz… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …
The consensus molecular subtypes of colorectal cancer
… (j) Gene set enrichment analysis of proteomic TCGA data (n = 81). Detailed statistics are in …
To classify a given CRC sample, the SSP first calculates the similarity S i,j of the CRC sample …
To classify a given CRC sample, the SSP first calculates the similarity S i,j of the CRC sample …
[PDF][PDF] Genome-wide methylation profiles reveal quantitative views of human aging rates
The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life. …
many fields, including disease prevention and treatment, forensics, and extension of life. …
[HTML][HTML] GSVA: gene set variation analysis for microarray and RNA-seq data
… ̂ r ( x ij ) , depending on whether x i j are continuous microarray, or discrete count RNA-seq …
convert z i j to ranks z (i)j for each sample j and normalize further r i j =|p/2−z (i)j | to make the …
convert z i j to ranks z (i)j for each sample j and normalize further r i j =|p/2−z (i)j | to make the …
AACR Project GENIE: powering precision medicine through an international consortium
The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …
an evidence base for precision cancer medicine by integrating clinical-grade cancer …
The National COVID Cohort Collaborative (N3C): rationale, design, infrastructure, and deployment
Objective Coronavirus disease 2019 (COVID-19) poses societal challenges that require
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …
[PDF][PDF] Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction
Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …
Clinical characterization and prediction of clinical severity of SARS-CoV-2 infection among US adults using data from the US National COVID Cohort Collaborative
Importance The National COVID Cohort Collaborative (N3C) is a centralized, harmonized,
high-granularity electronic health record repository that is the largest, most representative …
high-granularity electronic health record repository that is the largest, most representative …