User profiles for J. Guinney

Justin Guinney

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Cited by 30750

Consensus molecular subtypes and the evolution of precision medicine in colorectal cancer

…, J Guinney, S Kopetz, S Tejpar, J Tabernero - Nature reviews …, 2017 - nature.com
Critical driver genomic events in colorectal cancer have been shown to affect the response
to targeted agents that were initially developed under the 'one gene, one drug' paradigm of …

[PDF][PDF] The human tumor atlas network: charting tumor transitions across space and time at single-cell resolution

…, JM Ford, J Goecks, S Ghosh, JW Gray, J Guinney… - Cell, 2020 - cell.com
Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic tumor …

[PDF][PDF] The immune landscape of cancer

…, H Shen, TK Choueiri, JN Weinstein, J Guinney, J Saltz… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

The consensus molecular subtypes of colorectal cancer

J Guinney, R Dienstmann, X Wang, A De Reynies… - Nature medicine, 2015 - nature.com
… (j) Gene set enrichment analysis of proteomic TCGA data (n = 81). Detailed statistics are in …
To classify a given CRC sample, the SSP first calculates the similarity S i,j of the CRC sample …

[PDF][PDF] Genome-wide methylation profiles reveal quantitative views of human aging rates

G Hannum, J Guinney, L Zhao, LI Zhang, G Hughes… - Molecular cell, 2013 - cell.com
The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life. …

[HTML][HTML] GSVA: gene set variation analysis for microarray and RNA-seq data

S Hänzelmann, R Castelo, J Guinney - BMC bioinformatics, 2013 - Springer
… ̂ r ( x ij ) , depending on whether x i j are continuous microarray, or discrete count RNA-seq …
convert z i j to ranks z (i)j for each sample j and normalize further r i j =|p/2−z (i)j | to make the …

AACR Project GENIE: powering precision medicine through an international consortium

…, F Garcia, S Gardos, CD Gocke, BE Gross, J Guinney… - Cancer discovery, 2017 - AACR
The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

The National COVID Cohort Collaborative (N3C): rationale, design, infrastructure, and deployment

…, TD Bennett, DA Eichmann, J Guinney… - Journal of the …, 2021 - academic.oup.com
Objective Coronavirus disease 2019 (COVID-19) poses societal challenges that require
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …

[PDF][PDF] Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction

…, Z Kosaloglu-Yalcin, Z Huang, T Merghoub, J Guinney… - Cell, 2020 - cell.com
Many approaches to identify therapeutically relevant neoantigens couple tumor sequencing
with bioinformatic algorithms and inferred rules of tumor epitope immunogenicity. However, …

Clinical characterization and prediction of clinical severity of SARS-CoV-2 infection among US adults using data from the US National COVID Cohort Collaborative

…, D Gabriel, BT Garibaldi, AT Girvin, J Guinney… - JAMA network …, 2021 - jamanetwork.com
Importance The National COVID Cohort Collaborative (N3C) is a centralized, harmonized,
high-granularity electronic health record repository that is the largest, most representative …