Asthma is a common disease with a complex risk architecture including both genetic and
environmental factors. We performed a meta-analysis of North American genome-wide …

… RMG was supported by the National Institutes of Health (U01AI034989, 5K12HD052163,
P01 AI083050-02, R01-A122590, R01-A123240) and The J. David Gladstone Institutes (P01 …

Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide
variation from this region remain largely uncharacterized. We studied genomic …

Rationale: Independent replication of genetic associations in complex diseases, particularly
in whole-genome association studies, is critical to confirm the association. Objectives: A …

Rationale: Air pollution is a known asthma trigger and has been associated with short-term
asthma symptoms, airway inflammation, decreased lung function, and reduced response to …

Background Self-identified race or ethnic group is used to determine normal reference standards
in the prediction of pulmonary function. We conducted a study to determine whether the …

Most individuals throughout the Americas are admixed descendants of Native American,
European, and African ancestors. Complex historical factors have resulted in varying …

… of cell type h at CpG site j. The following generative model motivates the approach taken
in ReFACTor. We assume the methylation level at site j cell type h to be normally distributed …

Background Bronchial airway expression profiling has identified inflammatory subphenotypes
of asthma, but the invasiveness of this technique has limited its application to childhood …

10.7554/eLife.20532.001 Populations are often divided categorically into distinct racial/ethnic
groups based on social rather than biological constructs. Genetic ancestry has been …