Signaling pathways transmit information through protein interaction networks that are
dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-…

Transforming growth fazctor-β (TGFβ) family members regulate many developmental and
pathological events through Smad transcriptional modulators. How nuclear accumulation of …

Many components of the Wnt/β-catenin signaling pathway have critical functions in mammary
gland development and tumor formation, yet the contribution of glycogen synthase kinase-…

Background Accumulated literature suggests that the acidic nuclear phosphoprotein 32
kilodalton (Anp32) proteins control multiple cellular activities through different molecular …

Adenovirus serotypes 2 and 5 are taken into cells by receptor-mediated endocytosis, and
following release from endosomes, destabilized virions travel along microtubules to …

… Salomon-Escoto KI, Gravallese EM, Kay J. Assessment of control of rheumatoid arthritis disease
activity. Best Pract Res … Emmanouil Rampakakis & Joanna Dembowy … Joanna Dembowy …

The long-term challenge of proteomics as a tool for systems biology is to define the identities,
quantities, structures and functions of complete complements of proteins, and to …

Glycogen synthase kinase-3 (GSK-3) alpha and beta are central regulators of key developmental
pathways, including Wnt, Hedgehog and Notch, which control stem cell activities and …

The surface of a germanium internal reflectance element (IRE) was modified to bind 6X-histidine
(his)-tagged biomolecules. The step-by-step surface modification was monitored via …

… Nilsen-Hamilton (Iowa State University, Ames) for providing the Lcn 2 antibody; J. Dembowy
for technical assistance; and M. Saunders for scientific editing. TB is the recipient of a …