User profiles for J. Brandao-Neto

jose brandao-neto

Research Scientist, DIamond Light Source
Verified email at diamond.ac.uk
Cited by 2014

Osteopenia: a bone disorder associated with diabetes mellitus

…, LA Rezende, UBO Macedo, J Brandão-Neto… - Journal of bone and …, 2005 - Springer
Although osteopenia has been associated with human diabetes mellitus, the pathogenesis
of diabetic osteopenia is unclear. In the present study, we evaluated the effect of diabetes on …

Obesidade: uma doença inflamatória

…, J Brandão-Neto - Ciência & …, 2009 - revistaseletronicas.pucrs.br
Introdução: A inflamação do tecido adiposo na obesidade tem dado um novo enfoque a
essa enfermidade epidêmica e parece estar relacionada à patogênese de suas co-morbidades. …

Association between zinc and body composition: An integrative review

…, EC Grilo, L Leite-Lais, J Brandão-Neto… - Journal of Trace …, 2022 - Elsevier
Background Zinc deficiency is related to lean body mass reduction, fat deposition, and obesity.
Zinc acts in catalytic, structural, and regulatory functions, being an essential micronutrient …

[HTML][HTML] Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

…, A Aimon, P Ábrányi-Balogh, J Brandão-Neto… - Nature …, 2020 - nature.com
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral
drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or …

[HTML][HTML] Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase

…, Y Yosaatmadja, A Aimon, J Brandão-Neto… - Nature …, 2021 - nature.com
There is currently a lack of effective drugs to treat people infected with SARS-CoV-2, the
cause of the global COVID-19 pandemic. The SARS-CoV-2 Non-structural protein 13 (NSP13) …

The essential role of zinc in growth

J Brandão-Neto, V Stefan, BB Mendonça, W Bloise… - Nutrition research, 1995 - Elsevier
Zinc is known to play a relevant role in growth and development. The basic mechanisms of
action of this trace element are intimately linked to the structure and action of countless …

[HTML][HTML] Schistosomiasis drug discovery in the era of automation and artificial intelligence

…, BF Gomes, LR Souza Neto, J Brandao-Neto… - Frontiers in …, 2021 - frontiersin.org
Schistosomiasis is a parasitic disease caused by trematode worms of the genus Schistosoma
and affects over 200 million people worldwide. The control and treatment of this neglected …

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

…, A Aimon, JM Bennett, J Brandao Neto… - Science …, 2021 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–…

Low bone mineral density is associated to poor glycemic control and increased OPG expression in children and adolescents with type 1 diabetes

…, VMG Duarte, AD Luchessi, J Brandão-Neto… - Diabetes research and …, 2014 - Elsevier
Aims To investigate early alterations on bone mineral density (BMD) and RANK, RANKL and
OPG mRNA expression in peripheral blood leukocytes (PBL) in children and adolescents …

An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

…, JT Biel, E Kang, TJ Rettenmaier, J Brandao-Neto… - Elife, 2018 - elifesciences.org
10.7554/eLife.36307.001 Allostery is an inherent feature of proteins, but it remains challenging
to reveal the mechanisms by which allosteric signals propagate. A clearer understanding …