Adaptation to a changing environment is an essential feature of physiological regulation. The
day–night rhythm is translated into hormonal oscillations governing the metabolism of all …

The pineal gland is a neuroendocrine organ of the brain. Its main task is to synthesize and
secrete melatonin, a nocturnal hormone with diverse physiological functions. This review will …

… This night-specific protein, designated pineal night-specific ATPase (PINA), is expressed a
hundred times more at night than during the day (J Borjigin, SH Snyder, unpublished data). A …

… Reppert for the E-box luciferase constructs; J. Takahashi for the Bmal1 and Clock expression
plasmids; and M. Montminy for PGC-1α RNAi adenovirus. … Tiecheng Liu & Jimo Borjigin …

The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological
state of the brain immediately following cardiac arrest has not been systematically …

Materials and Methods Chemicals. Thioacetamide was purchased from Fisher Chemical Co.(Houston,
TX). All restriction enzymes and DNA modification enzymes were supplied by …

… Jallepalli for advice with subtractive hybridization technique, J. Nathans and D, Klein for
discussions, and Genentech for the mammalian expression vector. This work was supported by …

Wilson Disease (WD) usually presents in the first decades of life, although rare patients have
a later presentation. We report the clincial features, diagnostic evaluation, and outcome …

The brain is assumed to be hypoactive during cardiac arrest. However, animal models of
cardiac and respiratory arrest demonstrate a surge of gamma oscillations and functional …

… (J. Borjigin, unpublished data). PINA is an alternative transcript [36] produced from the
ATP7B [37] gene that is defective in human patients with Wilson disease (WD) [38]. Long Evans …