[HTML][HTML] Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing
Background Patients with prostate cancer may present with metastatic or recurrent disease
despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the …
despite initial curative treatment. The propensity of metastatic prostate cancer to spread to the …
[HTML][HTML] Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling
In vivo functional investigation of oncogenes using somatic gene transfer has been successfully
exploited to validate their role in tumorigenesis. For tumour suppressor genes this has …
exploited to validate their role in tumorigenesis. For tumour suppressor genes this has …
[HTML][HTML] Inference of transcription factor binding from cell-free DNA enables tumor subtype prediction and early detection
Deregulation of transcription factors (TFs) is an important driver of tumorigenesis, but non-invasive
assays for assessing transcription factor activity are lacking. Here we develop and …
assays for assessing transcription factor activity are lacking. Here we develop and …
[HTML][HTML] Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
Genomic alterations in metastatic prostate cancer remain incompletely characterized. Here
we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome …
we analyse 493 prostate cancer cases from the TCGA database and perform whole-genome …
Rapid identification of plasma DNA samples with increased ctDNA levels by a modified FAST-SeqS approach
BACKGROUND Recent progress in the analysis of cell-free DNA fragments [cell-free circulating
tumor DNA (ctDNA)] now allows monitoring of tumor genomes by noninvasive means. …
tumor DNA (ctDNA)] now allows monitoring of tumor genomes by noninvasive means. …
Advances in circulating tumor DNA analysis
The analysis of cell-free circulating tumor DNA (ctDNA) is a very promising tool and might
revolutionize cancer care with respect to early detection, identification of minimal residual …
revolutionize cancer care with respect to early detection, identification of minimal residual …
Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide
J Belic, R Graf, T Bauernhofer… - … journal of cancer, 2018 - Wiley Online Library
… have an unrelated sponsored research agreement with Servier within CANCER-ID, a project
funded by the Innovative Medicines Joint Undertaking (IMI JU), the salary of Jelena Belic …
funded by the Innovative Medicines Joint Undertaking (IMI JU), the salary of Jelena Belic …
Detection of ctDNA from dried blood spots after DNA size selection
Background Recent advances in the study and clinical applications of circulating tumor
DNA (ctDNA) are limited by practical considerations of sample collection. Whole-genome …
DNA (ctDNA) are limited by practical considerations of sample collection. Whole-genome …
[HTML][HTML] Untangling cortico-striatal connectivity and cross-frequency coupling in L-DOPA-induced dyskinesia
We simultaneously recorded local field potentials (LFPs) in the primary motor cortex and
sensorimotor striatum in awake, freely behaving, 6-OHDA lesioned hemi-parkinsonian rats in …
sensorimotor striatum in awake, freely behaving, 6-OHDA lesioned hemi-parkinsonian rats in …
Efficient workflow for the investigation of the catalytic cycle of water oxidation catalysts: Combining GFN‐xTB and density functional theory
JP Menzel, M Kloppenburg, J Belić… - Journal of …, 2021 - Wiley Online Library
Photocatalytic water oxidation remains the bottleneck in many artificial photosynthesis devices.
The efficiency of this challenging process is inherently linked to the thermodynamic and …
The efficiency of this challenging process is inherently linked to the thermodynamic and …