Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine
and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of …

To map the genetics of gene expression in metabolically relevant tissues and investigate
the diversity of expression SNPs (eSNPs) in multiple tissues from the same individual, we …

Genome-wide association studies (GWAS) have demonstrated the ability to identify the
strongest causal common variants in complex human diseases. However, to date, the massive …

Shotgun metagenomics methods enable characterization of microbial communities in human
microbiome and environmental samples. Assembly of metagenome sequences does not …

Prior to the epidemic that emerged in Haiti in October of 2010, cholera had not been
documented in this country. After its introduction, a strain of Vibrio cholerae O1 spread rapidly …

Beyond its role in host defense, bacterial DNA methylation also plays important roles in the
regulation of gene expression, virulence and antibiotic resistance. Bacterial cells in a clonal …

Viruses are the most abundant biological entities on Earth and play key roles in host ecology,
evolution, and horizontal gene transfer. Despite recent progress in viral metagenomics, the …

… (I,J) Distribution of IPD ratios for partially methylated m 6 dA sites and nonmethylated A's
based on aggregate analysis (I) and single-molecule level analysis (J). The inset provides an …

Horizontal gene transfer accelerates microbial evolution. The marine picocyanobacterium
Prochlorococcus exhibits high genomic plasticity, yet the underlying mechanisms are elusive. …

LamPORE™ is a rapid way of testing/screening large numbers of samples for the presence
or absence of SARS-CoV-2, the virus causing COVID-19. It combines barcoded multi-target …